DIRD_20-DIRD_Biosensors_and_BioMEMS-A_Survey_of_the_Present_Field.pdf

UNCLASSIFIED / /#@Fe@FFEGE=USE-ONET™ Defense Intelligence Reference Document = Acquisition Threat Support 31 March 2010 ICOD: 1 December 2009 DIA-08- 1003-020 Biosensors and BioMEMS: A Survey of the Present Field UNCLASSIFIED / -#@P-@=FEGii=USEONEH

UNCLASSIFIED / A2@R2@=EIGEA-UGEONE Biosensors and BioMEMS: A Survey of the Present Field Prepared by: (by\(3)-10 USC 424 Defense [ntelligence Agency Author: (b)(6) Administrative Note COPYRIGHT WARNING: Further dissemination of the photographs in this publication is not authorized. This product is one in a series of advanced technology reports produced in FY 2009 under the Defense Intelligence Agency, [BX):10 USC #2¢ Advanced Aerospace Weapon System Applications (AAWSA) Program. Comments or questions pertaining to this document should be addressed to [(b)(3):10 USC 424:(by6) |, AAWSA Program M…

UNCLASSIFIED / /®@R-@ EEG USE Ole Contents Introduction ......cc.cccncesccenusenecncennasnananeneesusnaneuauecasenenauensnseasacenauscauananenanenauansnenescnencean¥l What is BiOMEMS? .......sccccesurerescccrecevesusevevesusureversseseranuvenasesevusereraseseruese a verecureveserenes 1 Characteristics of BioMEMS........ vebsnoaneauausnencusnsccrsounase we vaueuavareuenaneuauanananens wenenane we 2 Categories of BiOMEMS.,..........cscsscesesecenececeneceseneseseresevenarevererensensurersenucesscususususuess 3 BiOMEMS Micromachines. ....cccssenesseessesnnnns we aeseeseeceanenanenecseuens we eece…

UNCLASSIFIED / SPOR-OFFGSR=- EEO NASA Space Applications for Microfluidic Systems .....cccccscsccenesuscersvsenssusenessaenss OF Microcantilever MEMs Sensors ....... dnananenananananccananananenenenanenananenananancnanenananananenanan . 36 CONCIUSION vcs sccencceneeeccuunecnceunssous:seuececeeneceuaeseusouvennancesneeueuusaceuneesannuaaeunaneneuassunnsusnass OO Figures Figure 1, Varieties of BioMEMS and S@NSOrs....scccscesscccnccsassenseseenssesccesscnensuseenseanen wn 2 Figure 2. Functional MEMS Micromachines Attached to Sensing Bioelectrodes.. wee 5 Figure 3. Schematic Diagram of a MEMS Moto…

UNCLASSIFIED / /®@R-OPPtGH-V6E-Oha- Figure 30. Microfluidics in Glass. SRCCC RT REST CCEA CREASE ERSTE RE ERR RE 32 Figure 31. Commercial Lab-Chip Devices That Allow Analysis for Biomarkers of Figure 32. Figure 33. Figure 34. Figure 35. Figure 36. Various Diseases Using On-Chip Electrophoresis in Microscale. .......... 34 Design of an Automated Cell Culture System for NASA Space Applications Incorporating Microfluidics and Integrated Optical COMPO NES wrcccnecenencrenencnenenenansnancnenenenenenanenanenauansusnengngnanatananenenenauananas 35 NASA Space Application of Microfluidic Cell Culture …

UNCLASSIFIED / SP@R°OFFEGEHUSE-Ont Biosensors and BioMEMS: A Survey of the Present Field Introduction Biomedical sensors and implantable devices employing micro- electromechanical technology will be important to the future of biomedicine. Once just science fiction, the notion of a bionic man is now becoming a reality through the application of microscale technologies. Today it is not unusual to have a friend or family member who has an implantable device, such as a pacemaker, defibrillator, cochlear implant, biosensor, neurostimulator, or insulin pump. We have only seen the beginning of this t…

UNCLASSIFIED / -F@R-@FEt6h-UGE-ONE-= What is BioMEMS? BioMEMS stands for biomedical micro-electro-mechanical systems. It is a name applied to biological and medical devices that are created using advanced fabrication processes that allow the devices to be very small relative to comparable devices produced by traditional techniques. BioMEMS devices can also exploit the microscale to provide new functions that are not practical or possible in large-scale devices. The name applies to an exceptionally wide variety of engineered devices that derive from electrical, mechanical, chemical, and molecul…

UNCLASSIFIED / P@R-OFFtGhtH USF OnrTr Varieties of BoOMEMs and Sensors Figure 1. Varieties of BioMEMS and Sensors. These BioMEMS devices were made at Arizona State University (ASU). They represent many of the areas of BioMEMS research. CHARACTERISTICS OF BIOMEMS Conceiving and designing BioMEMS devices requires a different perspective of the physical world. These devices can operate on principles such as capillary force, van der Waais forces, and electric-field forces. These forces become relatively strong when the size scale reaches very srnall dimensions. In the realm of the very smail, the …